<div dir="ltr">Hi Dorian,<div>Sounds like a good idea to me. You could do this in a tract-specific way (keeping in mind <a href="http://www.nitrc.org/pipermail/mrtrix-discussion/2014-March/000926.html" target="_blank">this previous discussion</a> on how to generate a tract-specific AFD measure).</div>
<div><br></div><div>I'm guessing when you say VBM, you mean voxel-based <i>analysis </i>(VBA)? I know historically <a href="http://www.ncbi.nlm.nih.gov/pubmed/15907311">some papers</a> have used VBM to refer to voxel-wise FA analysis. However, personally I prefer to reserve VBM for studies investigating morphometry using T1 segmentations, and use VBA for whole-brain voxel-wise studies in general. <br>
</div><div><br></div><div>In terms of voxel-based analysis and correlations with AFD, we have a method to do this (see the attached ISMRM abstract from last year). </div><div><br></div><div>Unfortunately this stats software (which we have renamed to connectivity-based fixel enhancement) won't be released in MRtrix for a few months. I'm currently still running experiments to identify optimal parameters and writing the paper.<br>
</div><div><br></div><div>Hope this helps,</div><div>Dave</div><div><br></div><div><br></div><div>
<br></div><div><br><div class="gmail_extra"><br><br><div class="gmail_quote">On 7 May 2014 04:07, Dorian P. <span dir="ltr"><<a href="mailto:alb.net@gmail.com" target="_blank">alb.net@gmail.com</a>></span> wrote:<br>
<blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left-width:1px;border-left-color:rgb(204,204,204);border-left-style:solid;padding-left:1ex"><div dir="ltr">Dear all,<div><br></div><div>I am attempting to compare FA and AFD (or HMOA) for their correlation with a third behavioral measure. The idea is to check whether the new measures have a better correlation with cognitive performance than the traditional FA. I cannot come up with a flow in this logic. I wanted to ask you opinion whether this comparison may or may not be appropriate. My intuition is that AFD (or HMOA) may be an excellent replacement of FA, of course not in VBM analyses, but in tract specific investigations. Am I correct with this?</div>
<div><br></div><div>Thank you.</div><div>Dorian</div><div>TJU</div><div><br></div><div><br></div></div>
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<br></blockquote></div><br><br clear="all"><div><br></div>-- <br><div dir="ltr"><div><b><font color="#ff6600">David Raffelt (PhD)</font></b></div><div><font color="#ff6600">Post Doctoral Fellow</font></div><div><br></div>
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