NYU CSC TestRetest News

A New Paper Published Using This TRT Dataset

Xi-Nian Zuo — Tue, 08 Feb 2011 2:56:35 GMT

Zuo XN, Kelly C, Di Martino A, Mennes M, Margulies DS, Bangaru S, Grzadzinski R, Evans AC, Zang YF, Castellanos FX, Milham MP. Growing together and growing apart: regional and sex differences in the lifespan developmental trajectories of functional homotopy. J Neurosci. 2010 Nov 10;30(45):15034-43.

Phyllis Green and Randolph Cōwen Institute for Pediatric Neuroscience, New York University Langone Medical Center, New York, New York 10016, USA. xinian.zuo@nyumc.org

Abstract: Functional homotopy, the high degree of synchrony in spontaneous activity between geometrically corresponding interhemispheric (i.e., homotopic) regions, is a fundamental characteristic of the intrinsic functional architecture of the brain. However, despite its prominence, the lifespan development of the homotopic resting-state functional connectivity (RSFC) of the human brain is rarely directly examined in functional magnetic resonance imaging studies. Here, we systematically investigated age-related changes in homotopic RSFC in 214 healthy individuals ranging in age from 7 to 85 years. We observed marked age-related changes in homotopic RSFC with regionally specific developmental trajectories of varying levels of complexity. Sensorimotor regions tended to show increasing homotopic RSFC, whereas higher-order processing regions showed decreasing connectivity (i.e., increasing segregation) with age. More complex maturational curves were also detected, with regions such as the insula and lingual gyrus exhibiting quadratic trajectories and the superior frontal gyrus and putamen exhibiting cubic trajectories. Sex-related differences in the developmental trajectory of functional homotopy were detected within dorsolateral prefrontal cortex (Brodmann areas 9 and 46) and amygdala. Evidence of robust developmental effects in homotopic RSFC across the lifespan should serve to motivate studies of the physiological mechanisms underlying functional homotopy in neurodegenerative and psychiatric disorders.

New Doc Added: TestRetest on ICA

Xi-Nian Zuo — Mon, 16 Nov 2009 3:13:54 GMT

We have added a new paper to be published in NeuroImage. In that paper, we systematically evaluated the test-retest reliability of TC-GICA derived RSFC measures over the short-term (<45 minutes) and long-term (5 - 16 months). Additionally, to investigate the degree to which the components revealed by TC-GICA are detectible via single-session ICA, we investigated the reproducibility of TC-GICA findings. First, we found moderate-to-high shortand long-term test-retest reliability for ICNs derived by combining TC-GICA and dual regression. Exceptions to this finding were limited to physiologicaland imaging-related artifacts. Second, our reproducibility analyses revealed notable limitations for template matching procedures to accurately detect TC-GICA based components at the individual scan level. Third, we found that TC-GICA component's reliability and reproducibility ranks are highly consistent.

Data not available in BrainScape

IPN NYU CSC — Thu, 22 Oct 2009 3:31:07 GMT

In reply to a question of someone that reviewed this resource: the data is not available in BrainScape.

Document on Preprocessing added

IPN NYU CSC — Thu, 22 Oct 2009 3:27:58 GMT

A document describing the preprocessing steps applied to the data available for download has been added to the Docs. In short the anatomical data have been defaced or skullstripped. No preprocessing was applied to the functional data. Of note, both MPAGE and EPI datasets were reoriented to RPI coord. system.

Test-Retest Resting-State fMRI Dataset (n = 25) Released

IPN NYU CSC — Tue, 01 Sep 2009 9:24:25 GMT

We are announcing the open release of the test-retest resting state fMRI dataset recently published by Shehzad, Kelly et al. (2009) in Cerebral Cortex ("The Resting Brain:
Unconstrained yet Reliable"; doi:10.1093/cercor/bhn256). Contained within this are datasets for 25 participants, each including two MPRAGE images (1 skull-stripped, 1 face-
anonymized), and three resting state fMRI scans. For the resting state scans, two of the scans were collected < 1hr apart in the same scan session, and the third scan was collected >5 months earlier.

These data are being shared without restriction on NITRC, with project name: NYU_CSC_TestRetest ( http://www.nitrc.org/frs/?group_id=274 ).