[Camino-users] Use datasynth for simulations

[Daniel Alexander]

The two tensor model seems like a reasonable place to start, but you should also look at the range of compartment models in (Panagiotaki et al NeuroImage 2012); see the White Matter Analytic Models tutorial on the camino website.  They provide much better models for single fibres than a single tensor model. They extend in theory to multiple fibre populations, where, similarly, they will be much better than the two-tensor model.  The extension to multiple fibres is straightfoward in principle, but not implemented directly in Camino at present so would require a bit of programming.

All the best.

Danny


On 2 Jun 2012, at 04:05, Leon wrote:

> Dear Camino experts
> 
> I need to test the effects of a compressive sensing technique on the diffusion MRI data. As I notice that Camino has quite powerful simulation capabilities, I hope I could get some help from forum. 
> 
> Currently, we want to test the effects of a novel compressive sensing technique on diffusion MRI. The goals are to test how sensitive the compressive sensing to the changes of SNR, b and diffusion encoding direction by comparing the fully sampled DTI-derived measures, such as FA, MD and crossing-fiber delineations with those with compressive factors. Since this novel compressive sensing is sensitive to the proportion of the moving voxels in images across diffusion directions, I think I will have to start from in-vivo images(correct me if I am wrong). What I am planning to do is as follows:
> 
> 1)  use modelfit to estimate the model parameters from a set of in-vivo images and use it as gold standard
> 2)  use datasynth to generate a series of images with different SNR, b, diffusion directions and apply compressive sensing with different reduction factors to test the effects on accuracy of the generated measures.
> 
> As I am fairly new to Camino, I wonder if someone could show me which model should provide the best trade-off between simulation accuracy and computational time. Currently, I think two-tensor model should be enough for me to test all these two goals, but I am not sure if they are the best, since the usage of the two-tensor model is not that popular.
> 
> Many thanks in advance!
> 
> Leon
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