[Mrtrix-discussion] SIFT: normalise to the b0 image

[Scott Cameron Kolbe]

Dear Donald, Rob and Dave

Just found this discussion whilst going through the archives. Sorry to bring it up again but I’ve been having similar concerns to Jan recently whilst working on multiple sclerosis data. The T2 “shine-through” effect that Jan is referring to in MS results from T2 signal enhancement that is not related to changes in CSF volume fraction.  Therefore hyperintense voxels in DWI, considered by SD to be highly restricted diffusion, are in fact not that different from surround tissue on the ADC map. 

This problem might be solved by acquiring low-B images for normalisation where freely diffusing fluid is essentially annulled but even lightly restricted water is not. However, we are sitting on quite a bit of data with only b=0 or b=3000. Do you think partial volume correction might be possible?  

cheers
Scott


Scott Kolbe
kolbes at unimelb.edu.au