Open Software License 3.0 Yes NITRC STAPLE MacOS, Windows, Linux Yes C++ Monet Dugan STAPLE is an algorithm for the Simultaneous Truth and Performance Level Estimation, which estimates a reference standard and segmentation generator performance from a set of segmentations. It has been widely applied for the validation of image segmentation algorithms, and to compare the performance of different algorithms and experts. It has also found application in the identification of a consensus segmentation, by combination of the output of a group of segmentation algorithms, and for segmentation by registration and template fusion. Further information is available at http://www.crl.med.harvard.edu 2009-3-01 5 - Production/Stable/Mature Version 1.4 STAPLE Win32 (MS Windows), English, Quantification, MR, MacOS, Windows, Nrrd, GIfTI, ANALYZE, DICOM, NIfTI-1, Console (Text Based), X11 Applications, 5 - Production/Stable/Mature, C++, Algorithm or Reusable Library, Segmentation, Image Display, Surface Rendering, End Users, Developers, Open Software License 3.0, Linux, Alzheimer Disease, Multiple Sclerosis, Stroke, Diabetes Mellitus, Epilepsy http://www.nitrc.org/projects/staple/, http://http://crl.med.harvard.edu/software/ monet.dugan@childrens.harvard.edu