Posted By: NITRC ADMIN - Mar 8, 2012
Tool/Resource: Journals
 

Biophysical and physiological origins of blood oxygenation level-dependent fMRI signals.

J Cereb Blood Flow Metab. 2012 Mar 7;

Authors: Kim SG, Ogawa S

Abstract
After its discovery in 1990, blood oxygenation level-dependent (BOLD) contrast in functional magnetic resonance imaging (fMRI) has been widely used to map brain activation in humans and animals. Since fMRI relies on signal changes induced by neural activity, its signal source can be complex and is also dependent on imaging parameters and techniques. In this review, we identify and describe the origins of BOLD fMRI signals, including the topics of (1) effects of spin density, volume fraction, inflow, perfusion, and susceptibility as potential contributors to BOLD fMRI, (2) intravascular and extravascular contributions to conventional gradient-echo and spin-echo BOLD fMRI, (3) spatial specificity of hemodynamic-based fMRI related to vascular architecture and intrinsic hemodynamic responses, (4) BOLD signal contributions from functional changes in cerebral blood flow (CBF), cerebral blood volume (CBV), and cerebral metabolic rate of O(2) utilization (CMRO(2)), (5) dynamic responses of BOLD, CBF, CMRO(2), and arterial and venous CBV, (6) potential sources of initial BOLD dips, poststimulus BOLD undershoots, and prolonged negative BOLD fMRI signals, (7) dependence of stimulus-evoked BOLD signals on baseline physiology, and (8) basis of resting-state BOLD fluctuations. These discussions are highly relevant to interpreting BOLD fMRI signals as physiological means.Journal of Cerebral Blood Flow & Metabolism advance online publication, 7 March 2012; doi:10.1038/jcbfm.2012.23.

PMID: 22395207 [PubMed - as supplied by publisher]



Link to Original Article
RSS Feed Monitor in Slack
Latest News

This news item currently has no comments.