Hi,

thank you for making this toolbox available! I have two questions:

Does there always need to be a contrast of 2 conditions? What if I want to see in 1 condition if 2 groups of subjects differ in strength of functional connectivity for certain ROI pairs?

And a more theoretical question, is creating a FC matrix for task condition 1 and 2 separately and subtracting them, the same as creating one FC matrix for the contrast 1-2?

Thanks,
Selma

Originally posted by Selma Lugtmeijer:
Hi,

You could in principle use a [1 0] contrast to map FC in condition A and then [0 1] for condition B and then compare the two, but it will change the interpretation. In this case, the FC matrix you map for each condition will be condition A vs the implicit baseline (i.e, everything else), which is slightly different to a [1 -1] scenario, where the FC matrix captures coupling between the task-modulated component of regional signals.

Ultimately it depends on whether you think the [1 0] scenario is interpretable.

hth
A 

Thank you for your explanation!