Posted By: NITRC ADMIN - Jul 27, 2018
Tool/Resource: Journals
 

Functional Connectivity of the Caudate in Schizophrenia Evaluated with Simultaneous Resting-State Functional MRI and Electroencephalography Recordings.

Neuropsychobiology. 2018 Jul 26;:1-11

Authors: Kirino E, Tanaka S, Fukuta M, Inami R, Inoue R, Aoki S

Abstract
BACKGROUND: Aberrant functional connectivity (FC) is increasingly implicated in the clinical phenomenology of schizophrenia. This study focused on the FC of the cortico-striatal network, which is thought to be disrupted in schizophrenia and to contribute to its clinical manifestations.
METHODS: We used simultaneous resting-state functional magnetic resonance imaging (rsfMRI) and electroencephalography (EEG) recordings to investigate FC in patients with schizophrenia. The study included 20 patients with schizophrenia and 20 healthy controls (HCs). Simultaneously recorded rsfMRI and EEG data were collected with an MR-compatible amplifier, and rsfMRI data were analyzed with the CONN toolbox to calculate FC. The study focused on the caudate, which was defined as the seed. We also performed between-group comparisons of standardized low-resolution electromagnetic tomography intracortical lagged coherence for each EEG frequency band.
RESULTS: Compared to HCs, patients with schizophrenia showed enhanced FC between the caudate nucleus and the posterior cingulate cortex, temporal, and occipital regions on rsfMRI. It is thus possible that HCs have negative FC between these regions, whereas patients with schizophrenia have non-negative FC. The EEG results showed no significant differences in oscillations or in FC between the groups in any frequency band in any region.
CONCLUSIONS: Increased FC in the caudate may represent aberrant between-network FC resulting from the disruption of segregation between networks.

PMID: 30048962 [PubMed - as supplied by publisher]



Link to Original Article
RSS Feed Monitor in Slack
Latest News

This news item currently has no comments.