Andrew,

I will clarify my previous post below.

Given that I did not find statistical significance in NBS when running a paired t-test between group 1 (before) and group 2 (after), I ran one-sample t-tests on my 26 subjects using the following design matrix:

1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1

to identify the most significant connections between ROIs for group 1 and again for group 2.

Then, in Excel, I ran a paired two-sample means test to compare the changes in significant connections between group 1 and group 2 and got a p-value = 6.40*10^-5.

My question is: how is this different than running a paired t-test in NBS that accounts for repeated measures with the first design matrix in my original post? When I run that, I get a p-value of 1.0.

Regards,

Anita