help > Very high effect sizes
Mar 26, 2025  01:03 PM | Erfan Naghavi - Tehran University of Medical Sciences
Very high effect sizes

Dear NBS Team,


Thank you for creating such an excellent tool. I am facing an issue that I believe you can help me resolve. I have computed a 22 × 22 functional connectivity matrix for a group of 850 participants (168 vs. 682). However, after applying NBS with a contrast array of [1, -1, 0, 0, 0, 0], I am observing exceptionally large effect sizes, reaching values as high as 11, 12, and even 14.


According to the NBS reference manual, the primary threshold is typically set between 2 and 4. However, using such a low threshold in my case results in an overly dense connectivity network, leading to unrealistic findings.


Given my situation, what would be an appropriate primary threshold, and how can I determine it? Would setting it to 10, 8, or 12 be reasonable? Additionally, what might be causing these unusually high effect sizes in my analysis?


Looking forward to your insights.


Best regards,
Erfan

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TitleAuthorDate
Very high effect sizes
Erfan Naghavi Mar 26, 2025
Andrew Zalesky Mar 27, 2025
Erfan Naghavi Mar 27, 2025
Andrew Zalesky Mar 27, 2025