Hello,

after reading the paper I still have some questions regarding the extent and methodology behind the DTI modification.  If I understood correctly, the DTI volume is modified after the first simulation of the tumor mass expansion, taking as input the degree of expansion or compression which affects the the diffusivity and principal diffusion direction.

My first question is, does the result of the infiltration process affect the DTI ?      or is it the DTI volume fixed after the tumor mass expansion, irrespective of the ammount of simulated infiltration?


Another question regarding the parameters that control the DTI,   can you provide typical values for them?   (white-matter tensor multiplier and gray-matter tensor multiplier)    what else would you suggest for generating the most reallistical DTI deformation (preferrably taking into account the infiltration and contrast-enhancement)?


 Thanks for your kind attention.

Best regards,

Andrés Méndez