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help > RE: NBS Statistical Test button - One Sample
May 29, 2014 02:05 AM | Andrew Zalesky
RE: NBS Statistical Test button - One Sample
Hi Juan,
I would like to clarify my previous response.
If you want to compare single individual to the sample of controls, you could use a design matrix of the form:
1 1
1 0
1 0
1 0
1 0
1 0
where the first row is the individual with epilepsy and the other rows correspond to the healthy controls.
Selecting a t-test with the contrast [0 1] will test whether the connectivity in the epilepsy individual is larger than controls. The contrast [0 -1] will test the opposite.
Andrew
Originally posted by Andrew Zalesky:
I would like to clarify my previous response.
If you want to compare single individual to the sample of controls, you could use a design matrix of the form:
1 1
1 0
1 0
1 0
1 0
1 0
where the first row is the individual with epilepsy and the other rows correspond to the healthy controls.
Selecting a t-test with the contrast [0 1] will test whether the connectivity in the epilepsy individual is larger than controls. The contrast [0 -1] will test the opposite.
Andrew
Originally posted by Andrew Zalesky:
Hi Juan,
You can't really test a null hypothesis about a single observation (e.g. a single individual with epilepsy compared to a group of controls). This is not something that is specific to the NBS, but rather general to statistics.
You can only test whether the patient group as a whole has no connectivity differences compared to the controls.
If you are interested about making inference at the level of an individual subject, you might want to consider predicting patients versus controls using something like a support vector machine.
Andrew
Originally posted by Juan Pablo Princich:
You can't really test a null hypothesis about a single observation (e.g. a single individual with epilepsy compared to a group of controls). This is not something that is specific to the NBS, but rather general to statistics.
You can only test whether the patient group as a whole has no connectivity differences compared to the controls.
If you are interested about making inference at the level of an individual subject, you might want to consider predicting patients versus controls using something like a support vector machine.
Andrew
Originally posted by Juan Pablo Princich:
Dear Teena and Prof. Zalesky;
First things first, thanks for this usefull toolbox! Hope you can help me with some questions...
I think Teena and i are facing similar issues, so i will try to elaborate on my problem and probably you may help both..
I ´ve calculated structural connectivity matrices for a reduced group of normal subjects (n=22), and also individual matrices of (n=21) individual epilepsy patients; were each patient is different from each other.
We would like to test the null hypothesis that each individual epilepsy patient has no connectivity difference compared against our normal sample of 21 subjects.
In other words, is it possible to avoid a group to group comparation in order to test for differences on each single epilepsy patient compared against the control group (n=22) using the NBS toolbox ? In the case it is true, what kind of test should we use and how could the matrix be designed to work properly ?
Hope i was clear enough
Thanks for your time and help
Juan Pablo
First things first, thanks for this usefull toolbox! Hope you can help me with some questions...
I think Teena and i are facing similar issues, so i will try to elaborate on my problem and probably you may help both..
I ´ve calculated structural connectivity matrices for a reduced group of normal subjects (n=22), and also individual matrices of (n=21) individual epilepsy patients; were each patient is different from each other.
We would like to test the null hypothesis that each individual epilepsy patient has no connectivity difference compared against our normal sample of 21 subjects.
In other words, is it possible to avoid a group to group comparation in order to test for differences on each single epilepsy patient compared against the control group (n=22) using the NBS toolbox ? In the case it is true, what kind of test should we use and how could the matrix be designed to work properly ?
Hope i was clear enough
Thanks for your time and help
Juan Pablo
Threaded View
| Title | Author | Date |
|---|---|---|
| Teena Moody | May 17, 2014 | |
| Andrew Zalesky | May 19, 2014 | |
| Teena Moody | May 29, 2014 | |
| Andrew Zalesky | May 30, 2014 | |
| Juan Pablo Princich | Jun 29, 2014 | |
| Andrew Zalesky | Jun 30, 2014 | |
| Juan Pablo Princich | Jun 30, 2014 | |
| Andrew Zalesky | Jun 30, 2014 | |
| Teena Moody | Jun 9, 2014 | |
| Juan Pablo Princich | May 29, 2014 | |
| Andrew Zalesky | May 29, 2014 | |
| Andrew Zalesky | May 29, 2014 | |
| Juan Pablo Princich | Jun 6, 2014 | |
| Andrew Zalesky | Jun 7, 2014 | |