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Notes:
The current release includes the 7T probabilistic atlas derived
from the group average magnetisation transfer image of the LC
(Priovoulos et al., 2018) with a semi-automated segmentation
pipeline (n=53, 52-84 years). The LC map was thresholded at
different levels (0%, 5%, 25%) to account for the trade-off between
sensitivity and specificity. Values within each voxels represent
the group-level probabilities.
The atlases can be binarised to create the corresponding LC masks
for different research purposes. The isotropic 0.5 mm ICBM152
(International Consortium for Brain Mapping) T1-weighted asymmetric
template (v2009b, Fonov et al., 2011) used during the registration
is also provided. The ICBM152 T1 template was cropped to match the
version of the MNI atlas in FSL6, under the copyright below:
"Copyright (C) 1993-2004 Louis Collins, McConnell Brain
Imaging Centre, Montreal Neurological Institute, McGill University.
Permission to use, copy, modify, and distribute this software and
its documentation for any purpose and without fee is hereby
granted, provided that the above copyright notice appear in all
copies. The authors and McGill University make no representations
about the suitability of this software for any purpose. It is
provided "as is" without express or implied warranty. The authors
are not responsible for any data loss, equipment damage, property
loss, or injury to subjects or patients resulting from the use or
misuse of
this software package."
When using the atlases, please cite:
An in vivo Probabilistic Atlas of the Human Locus Coeruleus at
Ultra-high Field
Rong Ye, Catarina Rua, Claire O'Callaghan, P Simon Jones, Frank H
Hezemans, Sanne S Kaalund, Kamen A Tsvetanov, Christopher T
Rodgers, Guy Williams, Luca Passamonti, James B Rowe
bioRxiv 2020.02.03.932087; doi: https://doi.org/10.1101/2020.02.03.93208...
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