[Mrtrix-discussion] FA vs. AFD/HMOA

[David Raffelt]

Hi Dorian,
Sounds like a good idea to me. You could do this in a tract-specific way
(keeping in mind this previous
discussion<http://www.nitrc.org/pipermail/mrtrix-discussion/2014-March/000926.html>on
how to generate a tract-specific AFD measure).

I'm guessing when you say VBM, you mean voxel-based *analysis *(VBA)? I
know historically some papers
<http://www.ncbi.nlm.nih.gov/pubmed/15907311>have used VBM to refer to
voxel-wise FA analysis. However, personally I
prefer to reserve VBM for studies investigating morphometry using T1
segmentations, and use VBA for whole-brain voxel-wise studies in general.

In terms of voxel-based analysis and correlations with AFD, we have a
method to do this (see the attached ISMRM abstract from last year).

Unfortunately this stats software (which we have renamed to
connectivity-based fixel enhancement) won't be released in MRtrix for a few
months. I'm currently still running experiments to identify optimal
parameters and writing the paper.

Hope this helps,
Dave






On 7 May 2014 04:07, Dorian P. <alb.net at gmail.com> wrote:

> Dear all,
>
> I am attempting to compare FA and AFD (or HMOA) for their correlation with
> a third behavioral measure. The idea is to check whether the new measures
> have a better correlation with cognitive performance than the traditional
> FA. I cannot come up with a flow in this logic. I wanted to ask you opinion
> whether this comparison may or may not be appropriate. My intuition is that
> AFD (or HMOA) may be an excellent replacement of FA, of course not in VBM
> analyses, but in tract specific investigations. Am I correct with this?
>
> Thank you.
> Dorian
> TJU
>
>
>
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>


-- 
*David Raffelt (PhD)*
Post Doctoral Fellow

The Florey Institute of Neuroscience and Mental Health
Melbourne Brain Centre - Austin Campus
245 Burgundy Street
Heidelberg Vic 3084
Ph: +61 3 9035 7024
www.florey.edu.au
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