InterVar is a bioinformatics software tool for clinical interpretation of genetic variants by the ACMG/AMP 2015 guideline. The input to InterVar is an annotated file generated from ANNOVAR, while the output of InterVar is the classification of variants into 'Benign', 'Likely benign', 'Uncertain significance', 'Likely pathogenic' and 'Pathogenic', together with detailed evidence code. InterVar is a command-line-driven software written in Python and can be used as a standalone application on a variety of operating systems—includingWindows, Linux, and MacOS—where Python is installed. wInterVar is a web server, which offers a graphical user interface for InterVar.