Alfonso,

I've been following this thread because I would like to accomplish something similar but with an ICC analysis.  How would one determine group-wise differences over time between controls and cognitive impairment level in patients?  I'm interested in finding those areas that are positively associated with cognitive change over time and are associated with FC over time AND are significantly different from controls.  My cognitive variable is continuous and mean-centered.  From prior discussions I am contrasting our in-scanner tasks over time as (follow-up minus baseline), such that any resulting import values reflect decline or increase over time.  I have three outside scanner behavioral/cognitive variables that are significantly different between groups from baseline, and ideally, I'd like to know how impairment/decline in the patients is related to areas engaged by our in-scanner tasks but also significantly different between groups.

Thanks,
Jeff