Hi,

I am conducting seed-based analyses with between-group comparisons.

Given the fact that I work with neurodegenerative patients, one of the reviewer has required gray matter atrophy correction. I have a few questions and any advice could help:

1) is it possible on CONN and has anyone ever tried it?
2) what are the best approaches? a voxel-wise correction using Biological Parametric Mapping? using total GM volume or GM volume in my seed ROI as a covariate?

If anyone has references to suggest me, that would be great!

Thanks!