Thanks Cole for your question and thanks Alfonso for answering

I would like to ask you  what I should modify in the TPM.
I've opened the default nii contained in the folder. My quesiton is now: what do you exactly mean when you suggest  to modify this TPM to include the lesion? how does this practically work? For instance: should I mask out the lesion from the standard TPM? 

Thanks a lot for your support

Gianluca