help > How to Interpret Between Subject + Between Condition Contrast
May 4, 2021  02:05 PM | Steven Meisler - Harvard University / MIT
How to Interpret Between Subject + Between Condition Contrast
Hello CONN team,

I have two groups (1 and 2) and two conditions (A and B). We hypothesize that in a given seed region, group 1 would show a greater activation in condition A relative to condition B, compared to group 2. To test this in CONN, we used the following contrasts, and I would like to make sure they are right to analyze this:

[1 -1 0 0] for between-subjects, corresponding to [Group1 Group2 age sex] covariates
[1 -1] for between conditions, corresponding to [ConditionA ConditionB]
 
In terms of the calculation, I see that CONN is reporting a t-statistic. Based on this, I presume that within a subject, the between-condition difference map is calculated first and used as the subject's first-level image, which is then fed into the group analysis employing a 2 sample t-test. Is this the correct way of interpreting the calculations for this set of contrasts?

Thank you,
Steven