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help > RE: what is the " normalization" in ALLF or LCOR?
Jul 27, 2021 05:07 PM | Emily Stern
RE: what is the " normalization" in ALLF or LCOR?
Originally posted by Alfonso Nieto-Castanon:
Hi Alfonso,
thanks for explaining this! I have a manuscript under review using CONN with global and local correlation. I used the within-subject normalization to run the analyses. A reviewer is asking about whether it makes sense to do this, and whether it might be of interest to look at non-normalized connectivity because global differences between subjects in connectivity (across all voxels) may be of interest. I wonder if you have any thoughts about this issue. Is there any concern with running the analysis without the within-subject normalization step, such as, connectivity values that may differ globally between subjects in relation to scanner artifacts but that are not meaningful in terms of brain function? Or is it a valid way of examining the data that looks for more global connectivity differences between subjects?
Thanks for any insight!
Best,
Emily
Hi Alfonso,
thanks for explaining this! I have a manuscript under review using CONN with global and local correlation. I used the within-subject normalization to run the analyses. A reviewer is asking about whether it makes sense to do this, and whether it might be of interest to look at non-normalized connectivity because global differences between subjects in connectivity (across all voxels) may be of interest. I wonder if you have any thoughts about this issue. Is there any concern with running the analysis without the within-subject normalization step, such as, connectivity values that may differ globally between subjects in relation to scanner artifacts but that are not meaningful in terms of brain function? Or is it a valid way of examining the data that looks for more global connectivity differences between subjects?
Thanks for any insight!
Best,
Emily
Threaded View
| Title | Author | Date |
|---|---|---|
| SUHONG KIM | Dec 22, 2020 | |
| Alfonso Nieto-Castanon | Jan 9, 2021 | |
| Emily Stern | Jul 27, 2021 | |
| Zaeem Hadi | Apr 26, 2022 | |
| Alfonso Nieto-Castanon | Apr 27, 2022 | |