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help > RE: Slice Timing correction with multi-site data
Jan 26, 2021 09:01 AM | Till Langhammer - Humboldt University Berlin
RE: Slice Timing correction with multi-site data
Hey all together,
I now this one is old. Still I will try to catch up with this.
In my point of view somebody (like me) would need a covariate for EVERY site like:
site 1 [1 1 1 0 0 0]
site 2[0 0 0 1 1 1]
...where the first three subjects are from site 1 and the last three belong to site 2...
In the second level analysis you would the need to include both covariates and set them zero for controlling for site (or scanner) effects...?!
As I have 9 different scanners, this question ist very important for me!
Thanks in advance!
Till from Berlin
Originally posted by Stephen L.:
I now this one is old. Still I will try to catch up with this.
In my point of view somebody (like me) would need a covariate for EVERY site like:
site 1 [1 1 1 0 0 0]
site 2[0 0 0 1 1 1]
...where the first three subjects are from site 1 and the last three belong to site 2...
In the second level analysis you would the need to include both covariates and set them zero for controlling for site (or scanner) effects...?!
As I have 9 different scanners, this question ist very important for me!
Thanks in advance!
Till from Berlin
Originally posted by Stephen L.:
BTW I forgot to mention that after
preprocessing, CONN does not care anymore about the different slice
timing, except the TR which you have to specify per subject on the
Setup first tab, you can specify a vector with the TR value for
each subject, eg if you have 4 subjects coming from 2 centers with
the first having TR 2 and second TR 1:
[2.0 2.0 1.0 1.0]
Then since you are studying data from multiple centers, make sure at Denoising step to add global correlation regression (called gCor in CONN) as a cofound, in order to normalize the signal across centers.
If you just setup those two things in CONN, normally you can then work with CONN as if all the subjects were from one single center.
If you want additional protection, you can also add a second-level covariate to specify which center each subject is from, something like that:
centers = [1 1 2 2]
for the example above, and then at 2nd-level analysis you can use this covariate to regress out between-center differences (contrast [0 1] where 0 is centers and 1 is Allsubjects), but normally if you use gCor it should not be necessary.
[2.0 2.0 1.0 1.0]
Then since you are studying data from multiple centers, make sure at Denoising step to add global correlation regression (called gCor in CONN) as a cofound, in order to normalize the signal across centers.
If you just setup those two things in CONN, normally you can then work with CONN as if all the subjects were from one single center.
If you want additional protection, you can also add a second-level covariate to specify which center each subject is from, something like that:
centers = [1 1 2 2]
for the example above, and then at 2nd-level analysis you can use this covariate to regress out between-center differences (contrast [0 1] where 0 is centers and 1 is Allsubjects), but normally if you use gCor it should not be necessary.
Threaded View
Title | Author | Date |
---|---|---|
ben anders | Jun 1, 2017 | |
Stephen L. | Jun 8, 2017 | |
Till Langhammer | Jan 26, 2021 | |
Till Langhammer | Jan 26, 2021 | |
Stephen L. | Jun 8, 2017 | |