help > Subnetwork from dNBS not a subset of significant edges from edge-wise Welch's t-test
Sep 12, 2023  05:09 AM | Rahul Biswas - University of Washington, Seattle
Subnetwork from dNBS not a subset of significant edges from edge-wise Welch's t-test

Hi,


Thank you very much for this great tool. I have a question, as follows. 


I performed two analyses after obtaining subject-specific directed functional connectivity: 1) used dNBS with primary threshold 1.8, 10K permuations, and size based on extent, to obtain a subnetwork with lower strength in diseased group compared to healthy group at significance level 0.05. 2) obtained edge-wise p-values for lower strength in diseased group compared to healthy group using Welch's t-test for each edge in the directed functional connectivities. 


However, the subnetwork obtained in analysis 1 is not a subset of edges having edge-wise p-value less than 0.05 in analysis 2. Isn't this wierd? I would really appreciate an explanation.


Some more detail: Only two edges in the subnetwork in analysis 1 have edge-wise p-value less than 0.05 in edge-wise Welch's t-test (analysis 2).


Thank you very much for explaining this.


Best regards,
Rahul

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TitleAuthorDate
Subnetwork from dNBS not a subset of significant edges from edge-wise Welch's t-test
Rahul Biswas Sep 12, 2023
Saqib Mamoon Sep 9, 2024
Andrew Zalesky Sep 10, 2024
Saqib Mamoon Sep 18, 2024
Andrew Zalesky Sep 18, 2024
Saqib Mamoon Sep 19, 2024
Saqib Mamoon Sep 11, 2024
Andrew Zalesky Sep 12, 2023
Rahul Biswas Sep 12, 2023
Andrew Zalesky Sep 13, 2023
Rahul Biswas Sep 14, 2023