Dear Alfonso,

I have conducted some Seed-Based Analyses (SBA) on nodes within the Default Mode Network (DMN) included in the network atlas. I have obtained very clear but surprising results. There are three groups, ranging from control to Group 1 with a degree of pathology, and Group 2 with a higher degree of pathology. I find that the group with the most pathology exhibits higher levels of anticorrelation between the parietal nodes of the DMN and parietal regions specific to task-related networks (attentional networks). This surprises me somewhat, as I would expect the greater anticorrelation between DMN and DAN/FPCN to be associated with the controls. However, it leads me to think that the group with more pathology may have a more dominant DMN during the fMRI session. Does this make sense? What post-hoc analyses would you recommend to shed more light on this phenomenon? Should I evaluate the temporal aspects of the ICAs belonging to the DMN? Perhaps consider a DYN-ICA analysis?

Best regards,

Benxa