Hi again Alfonso.

I conducted some DYN-ICA analyses with the aim of shedding light on this matter and trying to confirm my suspicion. I performed the analysis using the default settings in CONN and employed the ROIs listed in the network atlas, excluding the cerebellum (as it is not of interest, and for some subjects with large heads, data acquisition wasn't feasible). The first estimated circuit corresponds to the circuit of interest, as it shows regions of the DMN and some active visual regions, while the rest of the networks are hypoactive.

When it comes to looking for differences at the spatial level, I couldn't find any. However, when I explore the temporal aspects of the analysis for this circuit, I find that the group with a higher degree of pathology exhibits a higher frequency compared to the other two groups. Could this explain the higher levels of anticorrelation between task networks and the DMN in the group with the most pathology compared to the other two?

What do the three temporal parameters of DYN-ICA mean? I understand that frequency (where there are differences) refers to how often subjects are in that specific circuit. What do the other two signify, and where do these temporal parameters derive from? In another question, I think you mentioned that they are derived from the standard deviation (SD) values of each circuit. Could you elaborate a bit more on this to draft the methods section of this work?

Thank you very much, and I apologize for the length of the query. P.S. I have attached images of the one-sample result for the circuit of interest and the results of the group comparison for the temporal aspect of frequency.

Best regards,

Benxa